Clare is professor of translational cancer genetics in the division of genetics and epidemiology at the Institute of Cancer Research, London. Having trained in general medicine and specialised in clinical genetics, she also works as an NHS consultant in clinical cancer genetics at The Royal Marsden. Additionally, she is an honorary consultant in public health medicine at National Disease Registration Service (formerly at Public Health England). She spent 5 years working at Genomics England as clinical lead for the 100,000 Genomes Project Cancer Programme.

Her research focuses on statistical, population and public-health-related analyses to inform clinical implementation of cancer susceptibility genetics. Research areas include (i) discovery of novel genes/genomic variants associated with cancer susceptibility (iii) Clinical interpretation of variant pathogenicity (iii) assembly, linkage and longitudinal analyses of routine NHS datasets, including NHS genomic laboratory submissions and cancer registry data (iv) evaluation of the impact of genomic risk stratification on cancer early detection and prevention, and (v) pragmatic pathways for scaling of NHS genomic testing for BRCA genes (including the national NHS Jewish Community BRCA testing programme and BRCA-DIRECT programmes).